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David Prober is a Professor in the Department of Biology at the California Institute of Technology. He obtained a B.Sc. from the University of Manitoba in 1995 and a Ph.D. from the University of Washington in 2002. Prior to his current role, he served as an Assistant Professor at Caltech from 2009 until 2017. Prober's research focuses on the genetic mechanisms that govern sleep regulation in zebrafish, utilizing techniques such as genetics, behavioral assays, optogenetics, and whole-brain imaging. His work explores the neural circuits and genetic factors that are involved in sleep homeostasis, circadian rhythms, and sleep disorders. Notably, Prober's lab has identified key neuronal circuits in the hypothalamus that regulate sleep and influenced factors such as the neuropeptide NPVF and the epidermal growth factor receptor. His research aims to understand how disruptions in these mechanisms can lead to sleep disorders in humans, with a particular focus on genes associated with human sleep traits and autism spectrum disorder.
California Institute of Technology • Pasadena, CA
Conducting advanced research on genetic neural circuits that regulate sleep.
California Institute of Technology • Pasadena, CA
Initiated research on zebrafish models in sleep regulation.
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