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David S. Roos is a prominent faculty member at the University of Pennsylvania's Perelman School of Medicine, where he holds the position of E. Otis Kendall Professor in the Department of Biology. His research primarily focuses on molecular parasitology and host-pathogen interactions, with a particular emphasis on protozoan parasites belonging to the phylum Apicomplexa. Roos's laboratory employs a variety of modern techniques from cell biology, molecular genetics, biochemistry, and genomics to study the biology of these parasites and their evolutionary significance. Notably, Roos's work involves examining the mechanisms of drug resistance, comparative genomics, and the functional evolution of eukaryotic organelles. His research highlights the importance of Toxoplasma gondii and Plasmodium falciparum, with implications for human health, particularly regarding diseases like malaria and congenital neurological defects. Roos is dedicated to advancing the understanding of eukaryotic biology through the genetic analysis of these pathogens and the development of computational tools for genome analysis.
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