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David J. Segal is a professor at UC Davis Health, specializing in neurodevelopmental disorders. His research focuses on developing molecular therapies for neurologic disorders utilizing programmable DNA- RNA-binding platforms such as Zinc finger, TALE, and CRISPR/Cas9 technologies. This innovative approach aims to induce long-term changes in gene expression related to diseases while avoiding the complications associated with double-strand breaks. He uses a variety of delivery systems, including proteins, adeno-associated viruses, lipo-particles, and stem cells, to target brain disorders in animal models, which have been extensively evaluated at both molecular and behavioral levels. A major project in his lab involves investigating therapeutic strategies for reactivating silenced genes in conditions like Angelman syndrome. Dr. Segal collaborates with various international researchers to de-risk genetic therapies related to neurodevelopmental disorders.
Department of Computer Science. GRE is NOT required.