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David M. Tobin is a Professor in the Department of Molecular Genetics and Microbiology at Duke University. His research focuses on tuberculosis, specifically on the intricate interplay between mycobacteria and their hosts. His lab utilizes a combination of model organisms, genetics, and high-resolution microscopy to identify key pathways that mycobacteria use to infect hosts and manipulate the innate immune system. Tobin has made significant contributions to our understanding of host susceptibility to tuberculosis by using zebrafish, which are natural hosts for Mycobacterium marinum, the closest relative to Mycobacterium tuberculosis. The transparency of zebrafish embryos allows for detailed visualization of mycobacterial pathogenesis in live animals, providing insights into how specific host genetic variants affect susceptibility to tuberculosis. His active collaborations extend to research projects in Guatemala and Vietnam, focusing on the dynamics of TB transmission among HIV-infected patients.
Duke University • Durham, NC
Teaching advanced courses and conducting research in the field of molecular genetics and microbiology.
Duke University • Durham, NC
Conducted research and taught courses in molecular genetics and microbiology.
Duke University • Durham, NC
Started an independent research program focusing on immunology and mycobacterial infections.
Department of Biomedical Engineering (MS program)