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Deborah Anderson is a Principal Investigator and Senior Research Scientist at the Saskatchewan Cancer Agency, with a focus on cancer metastasis and cell signaling pathways. She earned her B.Sc. (Hons) and Ph.D. from the University of Manitoba. Her research primarily centers around the regulation of receptor tyrosine kinases (RTKs) and their roles in human cancers. One of her significant contributions is the elucidation of the PI3K/PTEN pathway, highlighting the dual regulatory roles of the p85 protein in kinase and phosphatase activities involved in lipid signaling. Anderson explores the mechanisms of receptor endocytosis and degradation within lysosomal compartments, emphasizing the oncogenic potential of dysregulation in RTK trafficking. Furthermore, she is investigating the metastasis suppressor protein CREB3L1, which is activated under stressful conditions in tumors, thereby inhibiting cell growth and migration. Her extensive analysis aims to provide deeper insights into the regulatory functions of both p85 and CREB3L1, particularly in the context of breast cancer.
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