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Dejian Ren is a Professor and the Graduate Chair in the Department of Biology at the University of Pennsylvania. His research focuses on cell developmental biology, neurobiology, behavior, and physiology, specifically the regulation of neuronal excitability and the biology of endosomes and lysosomes. His lab investigates the molecular mechanisms underlying neuronal excitability, emphasizing the role of ion channel proteins and the NALCN-UNC80-UNC79 protein complex, which serves as a major sodium leak channel regulated by extracellular ions and neuropeptides. Mutations in this complex can lead to significant intellectual disabilities. Ren employs various biophysical, biochemical, structural, and genetic approaches to elucidate the roles of endosomal and lysosomal membrane proteins in cellular function. He teaches courses such as Molecular Physiology and Molecular Evolution Physiological Functions.
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