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Denny Cottle is a Research Fellow at Monash University with a keen interest in cell differentiation processes and the mechanisms that lead to human diseases. He obtained his PhD under the supervision of Professor Christina Mitchell, where he investigated the molecular basis of apoptosis and muscle wasting, specifically in Reducing Body Myopathy. He then transitioned to the field of epidermal research in the laboratory of Professor Fiona M. Watt, focusing on the regulation of cell proliferation and differentiation through mouse genetic models. His findings uncovered a regulatory axis involved in sebaceous carcinoma and psoriasis-like differentiation of the interfollicular epidermis. Currently, he is part of Professor Ian M. Smyth's laboratory, continuing his research into human diseases utilizing mouse models, particularly relating to epithelial disorders such as Harlequin Ichthyosis and Polycystic Kidney Disease (PKD). Denny has become a Group Leader concentrating on Aurora Kinase (AURKA) and its role in driving cystogenesis in PKD, developing targeted protein degraders as potential therapeutics. His research aligns with the United Nations Sustainable Development Goals, contributing to innovations that can help in addressing global health challenges.
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