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Dewey G. McCafferty is a Professor in the Department of Chemistry at Duke University, where he has been a member since 2006. His research interests encompass broad areas of chemical biology and mechanistic enzymology, with a particular focus on molecular medicine. McCafferty's work engages in understanding chemical kinetic mechanisms and substrate specificity concerning the therapeutic importance of enzymes that posttranslationally modify chromatin. His studies include histone deacetylases, histone demethylases, and chromatin remodeling complexes. McCafferty has made significant contributions to developing phenotypic models for Parkinson's disease, utilizing innovative screening platforms to identify small molecules that restore complex biological pathways affected by Parkinson's toxicity. His research also explores the futalosine pathway of Chlamydia trachomatis, identifying potential narrow-spectrum antibiotic targets. Through his leadership in various NIH-funded research initiatives, he continues to advance the field of chemical biology and enzymology.
Duke University • Durham, NC
Serves as a Professor in the Department of Chemistry, leading research in chemical biology and enzymatic mechanisms.
Department of Biomedical Engineering (MS program)