Dr. Dibyadeep Datta

Biography

Dibyadeep Datta is a neuroscientist dedicated to elucidating the neurobiological mechanisms underlying cognitive dysfunction in major neuropsychiatric and neurodegenerative disorders, with a particular focus on schizophrenia and Alzheimer’s disease. His research aims to understand the cellular, molecular, and circuit-level perturbations that contribute to the pathogenesis of cognitive deficits, with an overarching goal of dissecting etiological mechanisms and identifying novel therapeutic targets. His work integrates multidisciplinary approaches, including molecular neurobiology, anatomy, multi-OMICS platforms, systems neuroscience, and translational models, to delineate vulnerabilities in higher-order cortical circuits essential for working memory, executive function, and goal-directed behavior. A central theme in Datta’s research is the characterization of synaptic circuit impairments in association cortices that are selectively affected in schizophrenia and Alzheimer’s disease. By probing the etiological drivers of disease pathogenesis—such as genetic risk variants, neuroinflammatory signaling, calcium dysregulation, and tau and amyloid pathology—he seeks to establish mechanistic links between molecular disruptions and functional circuit outcomes. Datta also emphasizes the development and evaluation of targeted intervention strategies aimed at restoring cognitive function in affected individuals, aspiring to bridge basic neuroscience with clinical translation and contribute to a deeper understanding of disease mechanisms while advancing therapeutic innovations for disorders marked by profound cognitive impairment.

Research Interests