Dr. Dieter Reinhardt

Biography

The Reinhardt laboratory is focused on understanding the components and mechanisms involved in the biogenesis and function of the extracellular matrix, as well as its pathological aspects and interactions with cells. Key research themes include the molecular mechanisms of matrix proteins and fibers, particularly in disorders affecting blood vessels, bone, skin, and adipose tissue. The lab investigates how extracellular matrix proteins instruct cells to differentiate, migrate, and proliferate, and how cells sense both normal and pathologically altered extracellular matrix environments. Further, the lab examines how the extracellular matrix regulates key growth factors such as the TGF-beta superfamily and aims to decipher the regulatory mechanisms mediated by microRNAs. Methodologically, the lab employs a wide spectrum of techniques, including in vitro biochemical and biophysical assays, cell biology methods using primary cells and transformed cell lines, as well as light and electron microscopic techniques. Additionally, in vivo studies are conducted with genetically modified mouse models. Reinhardt laboratory has published over 170 research articles, with more than 12,000 citations.

Research Interests