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The Dixon Lab at the Salk Institute for Biological Studies focuses on understanding how genomes encode information and the extraordinary challenge posed by this task. Researchers in the lab explore the role of three-dimensional genome organization within the nucleus in gene regulation. They employ a variety of molecular and computational biology approaches to study these complex biological questions. The lab utilizes innovative tools such as Hi-C, 3C, 4C, ChIP-seq, and RNA-seq to investigate higher-order chromatin structures and their influence on gene expression programs. A key component of their research is to decipher human genetic variation and how differences in gene expression among individuals can impact health and disease.