Dr. Dominic Campopiano

Biography

Professor Dominic Campopiano is known for his substantial contributions to the field of industrial biocatalysis, with a focus on natural product biosynthesis, enzymology, and the development of antibiotics. His research primarily revolves around the biosynthesis of sphingolipids, which are essential components of cell membranes in bacteria, mammals, and yeast. His collaborative work with Professor Jim Naismith from St. Andrews involved structural studies of serine palmitoyltransferase (SPT), which plays a crucial role in the sphingolipid biosynthetic pathway. Professor Campopiano's interests also extend to identifying protein drug targets, exploring essential metabolic reactions and drug detoxification mechanisms. He has employed dynamic combinatorial library techniques to develop reversible chemical libraries targeting glutathione S-transferases (GSTs). Furthermore, his research includes examining defensins, which are antimicrobial peptides contributing to innate immunity. He is involved in collaborative efforts to better understand antibiotic resistance, particularly in relation to cystic fibrosis pathogens, and aims to innovate novel antimicrobial agents. Professor Campopiano is also engaged in organizing conferences and promoting advancements in the area of antibiotic research.

Research Interests

Experience