Dr. Donald Coen

Biography

Donald Mark Coen is a Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard University. His research focuses on molecular approaches to herpesvirus replication and latency, utilizing herpes simplex virus (HSV) and human cytomegalovirus (HCMV) as model systems. Current projects in his lab investigate the biogenesis, mechanisms of repression, and biological roles of viral microRNAs during HSV infection. His work aims to provide insights into novel post-transcriptional regulatory mechanisms and to elucidate the functions of important herpesvirus DNA replication proteins. Coen's laboratory employs biochemical and structural analysis, including determining 3-D structures of proteins, exploring interactions of cellular proteins with herpesviruses, and utilizing single molecule methods. Additionally, he is involved in developing drug targets and new therapies for these viruses, focusing on established antiviral drug targets as well as novel interactions that can be inhibited to create effective treatments. Coen's studies contribute to a detailed understanding of complex viral proteins which are essential for rational drug design. Furthermore, he investigates mechanisms of HSV latency and pathogenesis, especially how viral gene regulation and microRNAs contribute to the establishment of latent infections in hosts.

Research Interests