Dr. Donald Ingber

Biography

Donald Ingber is the Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University. His research focuses on how microenvironmental cues, particularly mechanical forces through the extracellular matrix, regulate tissue development, physiology, and pathology. His laboratory conducts fundamental studies on the molecular basis of cellular mechanotransduction and develops microdevices and nanotechnologies for basic research as well as clinical diagnostics and therapeutics. A significant effort is aimed at the development of "Biomimetic Microsystems," utilizing miniaturization methods initially developed for microchips in the computer industry to create functional circuits within living cells. Currently, he is building intricate, three-dimensional models of human organs designed to improve patient treatments while replacing costly and time-consuming animal studies needed for drug development and toxicology applications. Additionally, his work involves studying the mechanical mechanisms that control angiogenesis, organogenesis, and tumor development, as well as creating biomimetic materials to promote organ regeneration and reverse cancer in vivo.

Research Interests