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The Maurice Lab is focused on investigating the role of cyclic nucleotide (cAMP and cGMP) compartmentation and signaling in human vascular cells, including arterial endothelial and smooth muscle cells. The research aims to understand how these cyclic nucleotides, which are fundamental in various cellular functions, can be regulated within specific compartments in cells. This regulation is crucial for developing therapeutic strategies for cardiovascular diseases, such as atherosclerosis and restenosis, and for enhancing our knowledge about processes like angiogenesis. The laboratory emphasizes the distinct functions of cyclic nucleotide phosphodiesterases (PDEs), which are the only enzymes that inactivate cAMP through hydrolysis. The work identifies the importance of PDEs in the specificity of signaling pathways and seeks to overcome existing therapeutic limitations associated with PDE targeting. Moreover, it explores various PDE variants in humans that operate uniquely within cAMP signaling compartments, aiming to refine current therapeutic approaches by leveraging these discoveries to mitigate adverse effects in conditions like atherosclerosis.
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