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Dr. Donna Peehl is a Professor (Research) in Urology at Stanford University, where she focuses on the development of realistic experimental models for benign and malignant prostatic diseases, including benign prostatic hyperplasia and prostate cancer. Her research involves establishing primary cultures of epithelial and stromal cells from prostatic tissues to investigate molecular and cellular biology aspects. She has pioneered the technique of tissue slice cultures (TSCs), which maintain essential epithelial-stromal interactions. TSCs have been developed into grafts for in vivo models and are a significant advancement in studying prostate conditions. Currently, Dr. Peehl's projects include the investigation of androgen receptor variants linked to aggressive prostate cancer, studying cell surface proteoglycans as biomarkers, searching for autoantibodies in serum for prostate cancer diagnosis, and characterizing cancer-related methylation using induced pluripotent stem cells. Her work is supported by various funding agencies, including the NIH and Prostate Cancer Foundation.
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