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Doris Stoffers, M.D., Ph.D., is a prominent researcher in diabetes and pancreatic beta cell biology at the University of Pennsylvania. Her laboratory focuses on understanding the transcriptional networks essential for the development and maintenance of pancreatic islet beta cells, which play a critical role in insulin production and glucose homeostasis. Dr. Stoffers' work investigates the pathways and molecular mechanisms that contribute to beta cell function and the pathophysiology of diabetes. Her research emphasizes the interaction of transcription factors, such as PDX1, with other proteins and how these interactions influence beta cell development, differentiation, and survival. Dr. Stoffers employs genomic and proteomic approaches alongside genetically modified mouse models to explore the role of key regulatory proteins in the context of environmental stressors like glucolipotoxicity. Her collaborative research also extends to clinical applications, addressing the genetic factors that influence diabetes pathogenesis. With a commitment to advancing diabetes research, her laboratory contributes to the NIH-funded Penn Diabetes Research Center, engaging in efforts that include the Human Pancreas Analysis Program. Dr. Stoffers is dedicated to mentoring the next generation of scientists, fostering an environment of inquiry and innovation in diabetes research.
Perelman School of Medicine at the University of Pennsylvania • Philadelphia, PA
Responsible for leading research in diabetes mechanisms and treatment strategies.
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