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Douglas Brash received his Bachelor of Science in Engineering Physics from the University of Illinois, minoring in Physiological Psychology, and completed his PhD in Biophysics at Ohio State University. His postdoctoral work at Harvard led to significant discoveries regarding UV-induced mutations, specifically the hotspots for mutations in E. coli. He proved that photoproducts from UV light are mutagenic. At Yale, his lab focuses on the unique mutation patterns induced by UV light and how they contribute to skin cancer development. His work has identified p53 as a crucial element in UV-induced apoptosis, preventing damaged cells from becoming cancerous. His research has revealed that individuals can carry a large number of clones of p53-mutant cells, which are essential in understanding skin cancer risk. Currently, he is working on identifying UV hypersensitive genome regions to assess sun exposure and future skin cancer risk using genomic dosimeters. His research encompasses various aspects of DNA damage and repair, melanoma, and photobiology, with applications in early detection of skin cancer through understanding UV exposure.
Administered via the Graduate School of Arts and Sciences (GSAS). GRE General is optional for PhD.