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Dr. Drew Weissman's laboratory focuses on the study of RNA innate immune system biology and its application in vaccine research and gene therapy. The main projects in the laboratory began with the use of mRNA encoding antigen delivery systems to load dendritic cells and promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and the translation of development applications in gene therapy. One key project develops new HIV envelope immunogens to induce broad responses of cross-reactive neutralizing antibodies. The laboratory continues studies that have identified a protein found in dendritic cells, macrophages, and epithelial cells that binds to the HIV envelope with high affinity. The main focus of the project is testing related molecules' functions in vivo to promote HIV genital tract infection.
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