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Dr. Drew Weissman's laboratory focuses on the study of RNA's role in innate immune system biology and its application in vaccine research and gene therapy. His main projects include using an mRNA encoding antigen delivery system to load dendritic cells and promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and the translation of findings into gene therapy applications. Another major focus of Dr. Weissman's research is on developing new HIV envelope immunogens that induce broad responses of cross-reactive neutralizing antibodies. His ongoing studies have identified a protein found in dendritic cells, macrophages, and epithelial cells that binds to the HIV envelope with high affinity, exploring the functional implications of these molecules in vivo and their potential to promote protection against HIV genital tract infection.
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