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Duane Wesemann is an Associate Professor in Medicine at Harvard Medical School. His research focuses on the immune response through the lens of antibody recognition and dynamics, utilizing methodologies such as mouse genetics, human studies, cellular biology, and single-cell transcriptomics. His work aims to elucidate the regulation and evolutionary implications of antibody repertoires, particularly how B cell antibody diversification occurs. By investigating the interactions between various immune cells and the mechanisms of somatic hypermutation, his laboratory seeks to understand trends in antibody evolution that can influence autoimmunity and allergy. His studies of jawless vertebrate immune systems provide insight into the fundamental features that enable somatic receptor evolution. Wesemann's findings have significant implications for developing enhanced responses to infectious diseases and improving vaccine efficacy. He emphasizes the importance of studying immune system adaptability and the genetic basis for antibody affinity maturation, highlighting the pivotal role of somatic mutations in shaping immune defenses against a wide array of pathogens.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.