Dr. Ed Chapman

Biography

Ed Chapman is a Professor and Investigator at the University of Wisconsin–Madison, affiliated with the Department of Neuroscience and the School of Medicine and Public Health. His research focuses on the molecular mechanisms underlying neuronal exocytosis, emphasizing synaptic transmission and plasticity. He leads multiple subgroups within his laboratory, where advanced techniques are utilized to study membrane trafficking and fusion processes that occur in neurons. His work has provided fundamental insights into the role of SNARE proteins in forming the core of the presynaptic fusion machinery, particularly regarding synaptotagmin 1 as a calcium sensor that facilitates rapid synaptic vesicle exocytosis. He investigates the sorting and life cycle of synaptic vesicle proteins, employing a variety of methods including single molecule fluorescence and cryo-electron microscopy to explore the dynamics of membrane fusion. Additionally, Chapman's lab explores concepts of synaptic plasticity and neurotransmitter release, and is committed to developing innovative techniques to advance the understanding of these processes.

Research Interests

Experience