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Ed Krol is a Professor at the College of Pharmacy and Nutrition at the University of Saskatchewan. His research focuses on medicinal chemistry and drug metabolism, with significant interests in xenobiotic metabolism, probe design, and the stability of compounds related to lignans and diphenylethanes. His studies include investigations into the stability and metabolism of di-catechol lignans, exploring their reactivity under oxidizing conditions to form dibenzocyclooctadienes. Krol has synthesized novel bifunctional compounds aimed at interacting with alpha-synuclein, a protein associated with the pathophysiology of Parkinson's Disease. He continues to design and prepare additional compounds to enhance binding properties related to this protein. Furthermore, Krol is designing synthetic pathways for the preparation of 18F-labelled compounds for use as Positron Emission Tomography imaging probes, with an emphasis on lignans and bifunctional compounds.
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