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Edward Chouchani is an Associate Professor in the Department of Cell Biology with a focus on deciphering the molecular mechanisms of metabolic disease dysfunction. His research utilizes mass spectrometry, biochemical, and genetic approaches to identify mitochondrial metabolic pathways that control protective and pathological cascades initiated by mitochondria. His work has primarily elucidated mechanisms of damage protection in pre-clinical models of cardiovascular and metabolic disease, particularly concerning the role of obesity and aging. Chouchani hypothesizes that understanding metabolic signals controlling healthy versus unhealthy adipose function can lead to new treatments for metabolic diseases. He has uncovered novel mechanisms defining the anti-obesity and anti-diabetic actions of thermogenic adipose tissue and focused on unraveling therapies targeting metabolic dysfunction driving myocardial infarction, a leading cause of mortality. His innovative work includes the development of in vivo biochemical and metabolomic methods establishing the mechanistic basis for cardioprotection and identifying novel metabolic pathways in the context of myocardial infarction.
Dana Farber Cancer Institute • Boston, MA
Focuses on deciphering molecular mechanisms of metabolic disease dysfunction through innovative research methods.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).