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Dr. Edward M. Marcotte is an evolutionary biochemist whose research broadly utilizes tools from proteomics, bioinformatics, and systems synthetic biology. His current work is focused on the interactions, dynamics, and evolution of proteins across the tree of life. Professor Marcotte has authored over 250 journal publications and holds more than 29 issued or in-process patents. He has received significant accolades including the National Institutes of Health Director's Pioneer Award and has been elected as a Fellow of the American Academy of Microbiology and the Royal Society of Chemistry. He co-founded the single molecule protein sequencing company Erisyon, Inc. The Marcotte lab at the University of Texas studies the regulation and organization of the human proteome, examining the dynamics that control proteins' intracellular abundances and their assembly into complexes. His lab leverages these insights to explore the mechanisms underlying human genetic diseases and to identify critical gene and protein interactions. With a large-scale perspective, his work employs evolutionary comparisons to discover conserved elements essential to biological systems. He consistently faces major technical and computational challenges leading to the invention of new technologies that enhance the study of protein function, expression, and localization.
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