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Eefjan Breukink is a professor at Utrecht University, specializing in Molecular Biophysics and Biochemistry. His research primarily focuses on antibiotic development and the fight against antibiotic resistance. Breukink's lab explores the bacterial cell wall synthesis pathway, particularly targeting Lipid II, a crucial precursor for peptidoglycan layer synthesis in bacteria. His work addresses the increasing global health threat posed by antibiotic-resistant bacteria, especially Gram-negative pathogens. The laboratory aims to develop novel screening approaches to discover antibiotics that effectively target the outer membrane of Gram-negative bacteria, while also collaborating with external institutions for innovative drug development. This multifaceted research effort combines structural elucidation of antibiotic-target complexes with the assessment of their efficacy and safety in mammalian infection models.
Utrecht University • Utrecht, Netherlands
Leader of research group focusing on molecular biophysics and biochemistry, with an emphasis on antibiotic resistance and development.
Department of Psychology