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Elazer Edelman leads the Edelman Lab at the Harvard-MIT Biomedical Engineering Center, which fosters a collaborative research environment where clinicians, engineers, and scientists work together to create translatable solutions for clinically relevant problems. The lab focuses on the application of continuum mechanics, digital signal processing, molecular biology, and polymeric controlled release technology to address a variety of challenges in cardiovascular science. Key projects include examining the interplay between mechanical support devices and native physiology, as well as the cellular and molecular mechanisms that transform stable coronary artery disease into unstable coronary syndromes. The laboratory is involved in innovative approaches including tissue-generated cells that deliver growth factors and study potential treatments for accelerated arterial disease, angioplasty, and bypass surgery. The Edelman Lab holds patents for drug-delivery devices, mechanical circulatory support approaches, and tissue-engineered implants, along with new drug formulations. Research interests also encompass machine learning and advanced computational modeling techniques, highlighting the integration of cutting-edge technologies in the field.