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Elizabeth Komives is a distinguished professor in the Department of Chemistry and Biochemistry at the University of California, San Diego. Her research focuses on understanding the structure, function, and dynamics of protein-protein interactions through various biophysical techniques, including Nuclear Magnetic Resonance (NMR) and mass spectrometry. The Komives lab is recognized for pioneering the use of hydrogen-deuterium exchange mass spectrometry (HDX-MS) to map protein-protein interfaces. Their work has uncovered critical insights into allosteric regulation, particularly in thrombin-thrombomodulin complexes. By demonstrating how thrombomodulin alters the dynamic ensemble of thrombin, her lab has revealed important mechanics that favor catalytic activity. Furthermore, her research on NFκB-IκB signaling has established new paradigms in the dynamics of transcription factors and their interactions with DNA. Komives is also actively involved in outreach and mentorship, focusing on increasing diversity in the field of Biophysics through various initiatives and training programs for underrepresented students.
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).