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Professor Meiering’s research group elucidates how the primary amino acid sequence of a protein determines its folding and function. Understanding the molecular mechanisms that govern protein folding and dynamics is essential for the comprehension of natural proteins, their misfolding and toxicity, and the role of variant proteins in disease and biotechnology. The lab employs a multidisciplinary approach that integrates various experimental and modeling methods to produce, engineer, and analyze recombinant protein variants in bacteria (E. coli). Techniques include biochemical and biophysical methods such as differential scanning calorimetry (DSC), multi-dimensional NMR spectroscopy, and atomic force microscopy. Current projects range from studying model proteins like Hisactophilin and engineered Adnectins to exploring the stability and solubility of target binding proteins for biologics. Overall, the research not only advances understanding of protein behavior but also aims at applying this knowledge toward medical and biotechnological advancements.
Includes fields like Clinical, Cognitive, Developmental, and Industrial/Organizational Psychology.