Dr. Elizabeth Ransey

Biography

Elizabeth Ransey is an Assistant Professor in the Department of Biological Sciences at Carnegie Mellon University. Her research focuses on the multifaceted roles of gap junctions, which are essential intercellular pores that enable direct communication and metabolic exchange between cells. The Ransey Lab investigates the formation of multimeric channels by connexin (Cx) proteins, which assemble into hexameric hemichannels that dock with adjacent cells to create conduits for the exchange of ions and small molecules. Ransey's work is crucial for maintaining tissue homeostasis, as mutations and abnormal expression of Cx proteins are linked to various diseases, including congenital deafness, epilepsy, neurodegeneration, and cancer. The lab explores the 21 human Cx isoforms expressed in different tissues and examines how specific configurations lead to functional diversity in properties such as permeability and gating. Employing a variety of techniques, including cellular biochemical assays and confocal imaging, Ransey aims to uncover novel Cx interactions and characterize isoform-specific properties to deepen our understanding of gap junction complexity and enhance intercellular communication to address health challenges.

Research Interests

Experience