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Ellen Rothenberg is the Edward B. Lewis Professor of Biology at the California Institute of Technology (Caltech). She earned her A.B. degree from Harvard University in 1972 and her Ph.D. from the Massachusetts Institute of Technology in 1977. Rothenberg's research focuses on the transcriptional networks underlying T-cell development and signaling. Her lab investigates the molecular mechanisms that govern developmental lineage choice, particularly in hematopoietic stem cells as they differentiate into T lymphocytes. She seeks to provide insights into the distinct stages of T-cell specific differentiation and the factors that drive lineage commitment. Rothenberg’s research methodologies include in vitro developmental biology, high-resolution characterization of individual cell states, and molecular genetics of gene regulation. Her work sheds light on the interactions among transcription factors and the chromatin landscapes that are altered during the lineage commitment process. Additionally, her group studies the evolutionary origins of T, B, and innate lymphocyte developmental programs by analyzing basal vertebrates.
California Institute of Technology • Pasadena, CA
Served as a Professor of Biology, focusing on transcriptional networks and T-cell development.
California Institute of Technology • Pasadena, CA
Held the Ruddock Professorship, continuing research in biology.
California Institute of Technology • Pasadena, CA
Current position as a Distinguished Professor, focusing on cellular development and regulatory mechanisms.
California Institute of Technology • Pasadena, CA
Currently holds the title of Edward B. Lewis Professor, leading research in T-cell biology.
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