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Ellie Tzima is a Professor of Cardiovascular Biology and a Wellcome Trust Senior Fellow at Oxford University. Her research is focused on mechanotransduction in the cardiovascular system, particularly the role of endothelial cells in sensing mechanical forces and their implications for vascular homeostasis and disease. The Tzima Group investigates how blood flow patterns, such as laminar and disturbed flow, influence endothelial cell behavior and gene expression, contributing to atherogenesis and atherosclerosis. The laboratory employs a multi-disciplinary approach, utilizing bioengineering techniques, molecular biology, and in vivo models to explore the mechanosensitive capabilities of endothelial cells. Recent findings include the investigation of genetic variants related to Coronary Artery Disease, emphasizing the role of the JCAD gene in endothelial cell responses to shear stress. Ongoing projects aim to uncover pathways regulating intercellular communication between endothelial cells and cardiomyocytes, with implications for heart development and disease.
Department of Politics and International Relations - Higher Level English requirement.