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Emanuela Ricciotti is a Research Associate Professor in the Department of Systems Pharmacology and Translational Therapeutics at the Perelman School of Medicine, University of Pennsylvania. She holds a Pharm.D. from 'G. d`Annunzio' University, Chieti, Italy (2001) and a Ph.D. in Science Aging from the same university (2005). Her research expertise lies in investigating the biochemical and pharmacological roles of the cyclooxygenase (COX) pathway in inflammation and cardiovascular disease. Dr. Ricciotti has contributed significantly to understanding human pharmacology concerning non-steroidal anti-inflammatory drugs (NSAIDs) and their potential harm to the cardiovascular system. Her current research focuses on defining the regulation of eicosanoids and bioactive lipids related to cardiovascular disease, aging, and responses to checkpoint blockade in cancer and viral infections including COVID-19. She is exploring mechanisms underlying NSAID-induced enteropathy and the time-dependent effects of low-dose aspirin on platelet reactivity and blood pressure. Dr. Ricciotti's work integrates studies in model systems with multi-omic immune profiling approaches, including lipidomics, single-cell transcriptomics, and metagenomics. She also researches cyclooxygenase biology, vascular biology, and a variety of topics in pharmacology and cardiovascular health.
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