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Emily Watts's research focuses on understanding the role of neutrophil metabolic signaling pathways in sensing the extracellular microenvironment that drives neutrophil phenotype and function in the lungs. Neutrophils are an essential component of the innate immune response, and inappropriate neutrophilic inflammation contributes to the pathology of several inflammatory lung diseases, including acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). Restoring the balance between functional immunity and pathological inflammation is crucial for treating these diseases. Neutrophils were once considered a homogenous population of cells with limited functions, but recent evidence suggests they are highly adaptable. Emily aims to uncover the intrinsic and extrinsic factors that determine neutrophil synthetic function, leading to new strategies to target pathological neutrophilic inflammation. Her research has shown that tissue neutrophils are biosynthetically active and utilize extracellular proteins to fuel de novo protein synthesis, with a dynamic proteome regulating their effector functions at injury sites. Emily has completed her medical training and holds a Wellcome Trust Clinical Fellowship, focusing on the effects of hypoxia on neutrophilic lung inflammation and continuing her clinical lecturer role in respiratory medicine in South East Scotland.
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