Dr. Emmanuel Mignot

Biography

Emmanuel Mignot is the Craig Reynolds Professor of Sleep Medicine at Stanford University and the Director of the Stanford Center for Narcolepsy. He is renowned for his groundbreaking work in uncovering the genetic basis of narcolepsy, a sleep disorder that affects approximately 1 in 2000 individuals. Mignot's pivotal research revealed that narcolepsy is caused by the immune-mediated destruction of hypocretin-producing neurons in the hypothalamus, which led to the identification of hypocretins as critical regulators of sleep. His research interests encompass neurobiology, genetics, and immunology related to narcolepsy, with additional focus on neuroimmunological aspects of brain disorders, autoimmune encephalitis, and paraneoplastic syndromes. Mignot employs advanced human genetics, proteomics, and genome-wide association studies to investigate sleep disorders and their underlying mechanisms. He actively conducts clinical trials and collaborates internationally to enhance understanding and treatment of sleep disorders such as narcolepsy and Kleine-Levin syndrome. Throughout his career, he has received numerous accolades, including the 2023 Breakthrough Prize in Life Sciences and election to several prestigious academies.

Research Interests

Experience

Courses