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Emmanuelle Cordat is a Professor in the Department of Physiology at the University of Alberta. Her research focuses on the renal handling of ions, with particular emphasis on the physiological role of bicarbonate transporters in the renal collecting duct. Her laboratory investigates the role of transporters expressed in various organs which participate in acid-base homeostasis and electrolyte balance. Imbalances in plasma bicarbonate levels can affect numerous physiological processes including oxalate homeostasis, kidney stone formation, water reabsorption, plasma pH balance, bile duct function, and even aspects of vision and hearing. Cordat's work primarily addresses the pathophysiology associated with renal intercalated cells and focuses on the kidney anion exchanger 1 (kAE1) protein. Mutations in this protein lead to distal renal tubular acidosis (dRTA), a disease characterized by growth failure, muscle weakness, and kidney stones. Her lab explores three main research areas: the pathophysiology of renal intercalated cell loss in dRTA patients, the persistence of kidney stones in patients with abnormal electrolyte balance, and the intercalated cells' role in innate immunity, especially concerning kidney stone formation, abnormal blood pressure, and urinary tract infections. Cordat's contributions to the understanding of these complex mechanisms are vital for improving clinical outcomes in affected populations.
Department: Mechanical Engineering and Engineering Management