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Enes Akyuz is a scientist at the McPherson Eye Research Institute, part of the University of Wisconsin-Madison. His research focuses on channelopathy, particularly defects in inwardly rectifying potassium channel 7.1 (Kir7.1) proteins that lead to congenital blindness. By exploring mutations in retinal pigment epithelium Kir7.1 channels, he aims to understand the mechanisms behind Leber congenital amaurosis (LCA). Akyuz employs both in-vitro and in-vivo models, including genetically engineered mice and patient-derived induced pluripotent stem cells (iPSC-RPE), to investigate cellular, tissue, and organ physiology related to these conditions. He utilizes advanced techniques such as patch-clamp, biological imaging, and various molecular methods in hopes of repairing Kir7.1 channel defects to develop effective treatments for blindness.
Department: Department of Computer Sciences