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Dr. Bennett received his PhD from Stanford University and carried out his postdoctoral work at Harvard Medical School. His lab focuses on understanding the fundamental principles of how proteins are destroyed within cells, particularly through the ubiquitin-proteasome system (UPS), which is essential for cellular quality control. The lab utilizes integrated approaches combining biochemistry and cell biology to investigate UPS activity and the regulation of deubiquitylating enzymes (Dubs). Their research reveals the mechanisms by which Dubs interact with ubiquitin ligases and how these interactions modulate protein degradation, an area critical to understanding diseases like amyotrophic lateral sclerosis (ALS) and cancer. The lab is developing technologies for global quantitative proteomic analysis of UPS function, aiming to monitor and identify conditions leading to UPS dysfunction, with eventual hopes of developing therapeutics to enhance quality control mechanisms in cells.
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).