Dr. Eric Greene

Biography

Eric C. Greene is a Professor in the Department of Biochemistry and Molecular Biophysics at Columbia University. He received his Ph.D. in biochemistry from Texas A&M University and conducted postdoctoral research at the National Institutes of Health with Kiyoshi Mizuuchi. His research focuses on utilizing single-molecule optical microscopy to study fundamental interactions between proteins and nucleic acids. The overarching goal of his work is to reveal the molecular mechanisms that cells use to repair, maintain, and decode genetic information. Greene's research combines biochemistry, physics, and nanoscale technology to address complex biological questions that are not readily approached by traditional biochemical methods. He has established robust experimental platforms for high-throughput single-molecule imaging of biochemical reaction mechanisms, enabling real-time observations of protein-nucleic acid interactions. His work aims to determine the physical basis of how proteins maintain genome integrity, especially in the context of homologous DNA recombination.

Research Interests