Dr. Eric Greene

Biography

Eric Greene is a professor at Columbia University, specifically in the Department of Biochemistry and Molecular Biophysics. He earned his Ph.D. in Biochemistry from Texas A&M University, where he worked under Dorothy Shippen. Following his doctoral studies, he conducted postdoctoral research with Kiyoshi Mizuuchi at the National Institutes of Health in Bethesda, Maryland. Greene's research group employs novel approaches in single-molecule optical microscopy to explore fundamental interactions between proteins and nucleic acids, aiming to uncover the molecular mechanisms by which cells repair, maintain, and decode genetic information. By integrating biochemistry, physics, and nanoscale technology, his team addresses complex biological challenges not easily tackled by traditional biochemical methods. Greene has established advanced experimental platforms that facilitate single-molecule imaging of biochemical reaction mechanisms in a high-throughput format, particularly within the context of protein-nucleic acid interactions. His work emphasizes the physical basis and mechanisms that proteins utilize to maintain genome integrity, with a special focus on reactions related to homologous DNA recombination.

Research Interests