Dr. Eric Yen

Biography

Eric Yen is an Associate Professor in the Department of Nutritional Sciences. His research focuses on the physiological functions of triacylglycerol (triglyceride; TG) synthesis, which serves as a storage and transport molecule for bioactive fatty acids, crucial for essential biological processes, including dietary fat absorption and milk production. His studies reveal that excessive accumulation of TG can lead to obesity and related metabolic diseases, such as type 2 diabetes. Yen utilizes genetically engineered mice to examine the physiological functions of the enzymes involved in TG synthesis. His current focus revolves around acyl CoA:monoacylglycerol acyltransferase (MGAT2), which mediates fat absorption in the small intestine. Notably, mice lacking this enzyme are protected from obesity and metabolic disorders typically induced by high-fat diets, while still absorbing normal amounts of dietary fat and exhibiting increased energy expenditure. His research combines biochemical and systems biology approaches to understand the molecular mechanisms of intestinal lipid metabolism, which regulates systemic energy balance. This research area is of critical importance, particularly in developing and testing MGAT2 inhibitors for efficacy, and expanding the understanding of the roles of MGATs and other genetic and dietary factors in modulating energy balance.

Research Interests