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Erika L.F. Holzbaur is the William Maul Measey Professor of Physiology at the University of Pennsylvania. She obtained her B.S. in Chemistry/History from the College of William and Mary in 1982, followed by a Ph.D. in Biochemistry from Pennsylvania State University in 1987. Her research expertise focuses on microtubule-based motility and the cytoplasmic dynein motor protein, along with the activator dynactin. Her lab investigates the mechanisms behind force production in motor functions, cargo coupling regulation, and the dynamics of dynein and dynactin within the cytoskeleton. The implications of her work are particularly relevant to understanding neurodegenerative diseases and the pathological effects associated with dynein/dynactin dysfunction. Holzbaur's lab employs various experimental approaches, including in vitro motility assays, live-cell microscopy, and the development of transgenic mouse models for motor neuron diseases. Her ongoing projects elucidate cellular effects of dynactin mutations and the role of microtubules in neuronal transport and development.
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