Dr. Esteban Dell Angelica

Biography

Esteban Dell'Angelica is a Professor and Vice Chair in the Department of Human Genetics at the David Geffen School of Medicine at UCLA. He holds a PhD from the University of Buenos Aires, Argentina, where he focused on the isolation and biochemical characterization of previously unknown calcium-binding proteins in neutrophils. Following his doctoral studies, he completed postdoctoral training in the laboratory of Juan S. Bonifacino at the National Institutes of Health in Bethesda, Maryland, where he identified and characterized components of the molecular machinery involved in protein trafficking within endocytic and late secretory pathways. His work has implications for understanding human diseases, particularly those associated with mutations in these pathways, such as Hermansky-Pudlak syndrome type 2. At UCLA, he has been instrumental in identifying and characterizing multi-subunit protein complexes, including BLOC-1 through BLOC-3, which are essential for the biogenesis of lysosome-related organelles, melanosomes, and platelet dense granules. Dr. Dell'Angelica is also a member of a multidisciplinary team at UCLA that collaborates with the Undiagnosed Diseases Network to address rare and poorly understood human diseases.

Research Interests