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Evan Weber is an Assistant Professor in the Department of Pediatrics at the University of Pennsylvania. His research focuses on improving the efficacy of chimeric antigen receptor (CAR) T cell therapy, addressing key challenges such as T cell exhaustion caused by chronic CAR signaling and high tumor burden. He has conducted postdoctoral research demonstrating that a transient cessation of CAR signaling can restore the anti-tumor function of exhausted CAR T cells through epigenetic remodeling. His independent research program aims to endow human CAR-T cells with resistance to exhaustion, potentially improving their therapeutic durability. Utilizing pharmacologic, gene-editing, and bioengineering techniques, his lab seeks to identify and modulate critical transcriptional and epigenetic pathways that redirect T cells toward therapeutic states. By employing multi-omics analyses of patient-derived CAR T cells, his work aspires to link epigenetic features to cell functionality and patient outcomes, thus informing strategies to enhance CAR-T cell efficacy against cancer.
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