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Fanxin Long, Ph.D., is a professor in the Department of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania. His research focuses on understanding the fundamental mechanisms underlying normal skeletal development and the pathophysiology of bone disorders. The Long Laboratory is dedicated to uncovering key steps in the molecular and metabolic regulation of skeletal cell differentiation and function. Major themes in his work include exploring the roles of critical developmental signals such as Hedgehog, Wnt, Notch, and BMP in regulating skeletal development and homeostasis. His research utilizes a combination of genetic mouse models and advanced techniques, including single-cell sequencing and genetic lineage-tracing, to investigate skeletal stem and progenitor cells and their contributions to bone maintenance and pathology. The lab’s ongoing projects aim to dissect the underlying mechanisms of metabolic and epigenetic reprogramming in skeletal cells, as well as to identify therapeutic targets for treating various skeletal diseases, including osteoarthritis and diabetic osteopenia.
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