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Fanxin Long, Ph.D., is a professor in the Department of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania. His research laboratory focuses on understanding the fundamental mechanisms underlying normal skeletal development and the pathophysiology of bone disorders. With a background in developmental biology, Long's studies examine key developmental signals including Hedgehog, Wnt, Notch, and BMP that play a critical role in skeletal development and homeostasis. His research delves into the metabolic and epigenetic regulation of skeletal cell differentiation and function, with particular emphasis on conditions such as diabetic osteopenia and skeletal aging. Long employs various methodologies, including single-cell sequencing technology and genetic lineage tracing, to identify skeletal stem/progenitor cells in mice and assess their contributions to bone maintenance and pathology. He aims to uncover therapeutic targets for treating a range of skeletal diseases, highlighting the impact of metabolic disruptions on cellular activities within bone and cartilage.
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