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Dr. Fanxin Long is a Professor in the Department of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania. His research focuses on understanding the fundamental mechanisms underlying normal skeletal development and the pathophysiology of bone disorders. The Long lab seeks to uncover key steps in molecular and metabolic regulation of skeletal cell differentiation and function, with the overarching goal of discovering therapeutic targets for treating skeletal diseases. His studies have centered on the roles of key developmental signals such as Hedgehog, Wnt, Notch, and BMP in regulating skeletal development and homeostasis. Through mouse genetic studies, the lab has defined specific functions of these signals in the differentiation of bone and cartilage cells. In addition, molecular and biochemical studies have led to the discovery that developmental signals can alter cell fate and activity as part of reprogramming cellular metabolism. The lab has identified cell-intrinsic disruptions in glucose metabolism as a pathogenic basis for osteoarthritis and diabetic osteopenia, utilizing single-cell sequencing technology and genetic lineage-tracing methodologies to examine skeletal stem/progenitor cells.
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