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Francesco Boccalatte’s research focuses on the epigenetic mechanisms that contribute to cancer growth, resistance, and treatment. His main area of study is acute leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL). His team explores changes in chromatin conformation that drive the expression of oncogenes favoring the initiation and progression of leukemia. In parallel, he investigates how chromatin architecture regulates normal hematopoietic differentiation and how these mechanisms are hijacked in leukemia. To test these mechanisms, they employ a vast array of genome-wide screenings using genome editing technologies. These pipelines, combined with advanced computational algorithms, assist in predicting therapeutic targets. Additionally, the lab utilizes single-cell approaches and high-resolution microscopy for drug screenings to interrogate the crosstalk between cancer cells and their microenvironment and its impact on tumor resistance. The ultimate goal of Dr. Boccalatte’s work is to integrate the results from these studies towards the development of efficient targeted treatments for cancer patients, with a focus on designing new therapies to prevent tumor relapse and resistance to chemotherapy.
NYU Grossman School of Medicine • New York, NY
Teaching in the Graduate Education program.
Open Program in Biomedical Sciences (Vilcek Institute) covers departments like Biochemistry, Pathology, Neuroscience, Microbiology, etc.