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Francisco J. Sánchez-Rivera was born and raised in Mayagüez, Puerto Rico. He obtained his bachelor's degree in Microbiology from the University of Puerto Rico at Mayagüez and completed his PhD in Biology at MIT. While a PhD student under Tyler Jacks, he utilized CRISPR to systematically investigate cancer drivers in vivo and identify genotype-specific dependencies in lung adenocarcinoma. As an HHMI Hanna H. Gray Fellow, he developed and applied CRISPR base editing methods to engineer mutations with high efficiency and precision in cells and tissues of living animals, allowing for quantitative interrogation of cancer variants at scale. His overarching research goal is to elucidate the cellular and molecular mechanisms through which disease-predisposing mutations interact with an individual’s genome to influence the development of diseases such as cancer. He employs sophisticated genome editing technologies to manipulate DNA within cells and organisms with single nucleotide precision. Sánchez-Rivera joined the MIT faculty in 2022 as an Assistant Professor in the Department of Biology and is a member of the Koch Institute.
Massachusetts Institute of Technology • Cambridge, MA
Joined as part of the Eisen Chang Career Development Professorship, focusing on research in cancer genomics.