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Francois Spitz is a Professor at the University of Chicago in the Department of Human Genetics. His research focuses on the architecture of the genome and how it contributes to the specificity and robustness of gene expression programs that govern embryonic development and cell differentiation. Spitz is particularly interested in understanding how vertebrate genomes, which contain hundreds of thousands of regulatory sequences, influence the expression of genes located hundreds of kilobases away. His main goal is to unravel how the folding of the genome into specific domains and dynamic structures transforms dispersed information into highly specific regulatory ensembles. His work also explores how perturbations in these processes, especially those due to chromosomal rearrangements, can lead to developmental and oncogenic pathologies, thus contributing to our understanding of animal evolution.
Department of Philosophy